Fenbendazole (also known as mebendazole) is an antiparasitic drug commonly used to treat parasitic infections in dogs and humans. Although studies have shown that fenbendazole can suppress cancer cell growth in cell cultures and mice, there isn’t enough evidence from randomized clinical trials to show that it can cure cancer in humans.
A recent viral Facebook post described the case of a man who claims to have overcome metastatic cancer using fenbendazole and other natural treatments. He describes his anecdotal experience in a way that suggests he may have found a “cure”, but the facts aren’t clear.
Most of the people interviewed by researchers who investigated this story said they heard about fenbendazole cancer treatment from acquaintances or family members, rather than TV or YouTube. Some of the respondents also said they got information about fenbendazole from the Internet or from friends on social media.
Some research has shown that fenbendazole, like its relative mebendazole, makes tumor cells more sensitive to radiation by disrupting the binding of the beta subunit of helminithic tubulin with the alpha subunit of normal cell tubulin, which is needed for proper cell growth. Other studies have demonstrated that fenbendazole can reduce the number of DNA repair genes that are activated in irradiated cancer cells.
Other research has shown that fenbendazole does not prevent the formation of lung metastases after irradiation of human melanoma and prostate cancer cells. In these experiments, the cells were treated in hypoxia for 2 h with various doses of fenbendazole, then subjected to irradiation. The survival curves were similar for both unirradiated and irradiated cultures, but the addition of fenbendazole dramatically increased the sensitivity of the cells to radiation. fenbendazole cancer treatment