Joe Tippens thought he was going to die of small-cell lung cancer, but then a veterinarian told him about something he’d read on the internet: that scientists had discovered that fenbendazole, a dog dewormer that he took for hookworms and roundworms, seemed to work against cancer. It was cheaper than chemo and immunotherapies, and he had three months to live anyway, so he said, why not? It might even help him meet his new grandson.
A group of 20 lung cancer patients with stage one to four cancer were interviewed using semi-structured questions. The interviews focused on the channels where participants acquired general and false cancer information, as well as their perception of that information.
Most participants reported that they acquired cancer information through television. They also reported obtaining general and false information through the Internet. Some patients actively searched for complementary and alternative cancer information online. These results suggest that patients are often exposed to false information on a daily basis.
The most important channel for acquiring general cancer information was through the Internet community and portal sites. However, the quality of that information was low and many of the interviewees believed that it needed to be verified by experts.
Most interviewees were skeptical of complementary and alternative medicine. They also had a negative attitude toward herbal and natural remedies. However, some patients were willing to consider them as part of a holistic approach to their care.
Febendazole is an antihelminthic agent that has been shown to have cytotoxic and antitumor properties in laboratory models. Its antitumor activity is attributed to its ability to inhibit cell growth by blocking the synthesis of tubulin, a polymer that makes up microtubules in cells. These properties are similar to those of a number of cytotoxic anticancer agents, including vinca alkaloids and taxanes.
In experiments involving the EMT6 mammary tumor cell line, high concentrations of fenbendazole were toxic to the cells in vitro. This toxicity increased with increasing incubation time and was enhanced under conditions of severe hypoxia. Febendazole also augmented the cytotoxicity of the antineoplastic agent docetaxel in these cells. dewormer for cancer